• Capabilities
  • Resources
  • About Us
  • Careers
  • Contact Us

February 03, 2021 6:00pm ET | Application of Variable Pathlength Technology for Rapid Determination of Dynamic Binding Capacity

February 03, 2021 | 6:00pm ET

Application of Variable Pathlength Technology for Rapid Determination of Dynamic Binding Capacity​​

An ever-increasing demand for biomolecule-based therapies is driving biopharmaceutical companies to accelerate process development activities to remain competitive in today’s industry. Within the downstream process development space, affinity chromatographic media is widely used for primary recovery of bio-therapeutics such as monoclonal antibodies, Fc fusion proteins, etc. Optimization of the primary recovery step includes determination of dynamic binding capacity (DBC) for target protein molecule and can be a lengthy process using traditional methods. KBI Biopharma has applied the use of variable pathlength technology for rapid generation of breakthrough curves and determination of DBC for resin selection. Flow VPE, a variable pathlength UV detector from C Technologies, is integrated with the chromatographic system for real time generation of breakthrough curves, reducing the time and cost associated with the development of the primary capture step. This technology accelerates the overall process development timeline and, to a degree, helps offset the high cost of the affinity media. Case studies are included.

During this webinar participants will learn: 

  • Learn application of variable pathlength technology in determination of dynamic binding capacity for primary recovery step during downstream processing of biotherapeutics
  • Discover advantages over traditional methods and impact on process development timeline
  • Review applicable case studies

    Register Now

About the Presenter

Rashmi_Bhangale_headshot

Rashmi Bhangale, Ph.D.

Rashmi received her Ph.D. in Chemical Engineering from the Institute of Chemical Technology in Mumbai, India. There her work focused on understanding the mechanisms involved in chromatographic separations for a priori prediction of performance of purification processes using chromatography. Rashmi joined the Downstream Process Development team at KBI Biopharma in North Carolina in 2018. Currently, a Process Development Scientist, Rashmi is involved in the development and transfer of purification processes for a variety of molecules including monoclonal antibodies, Fc fusions, and enzymes.

 

 

Related Resources

January 21, 2021 11:00am ET | A CDMO Approach to Viral Safety for Biotechnology Products​
December 3, 2020 11:00am ET | High-throughput and Automated Approaches for Accelerated Process Characterization and Biotherapeutic Manufacturing​
Contact Us

Are you looking to accelerate your program or just want to learn more about our services?

Connect with our team and we will get back to you quickly.

View Capabilities

Connect with our team and we will get back to you quickly.

View Capabilities
  • Capabilities
  • Resources
  • About Us
  • Careers
  • Contact Us
JSR_Logo_footer-01
  • KBI on Facebook
  • KBI on Twitter
  • KBI on Google+
  • KBI on LinkedIn

Copyright © 2019 KBI Biopharma. All Rights Reserved. | Privacy Policy