Doing More With Microbes.

Raising The Bar On Microbial Expression And Manufacturability, KBI Uses An Early Optimization Workflow To Ensure Manufacturing Success.

As A Result, More Molecules Are Manufactured Using an E. Coli Expression System Than Ever Before.

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The Right E. coli Manufacturing Process starts with Early Screening and Optimization.

Ahead of upstream process development, KBI focuses on microfermentation screening for microbial cell line development (CLD) to yield consistent, high titers across strains and molecules. At KBI, our years of vertical process integration knowledge and data can allow us to scale directly into 10L stainless steel or 30L single-use systems.

E. Coli Expression

High Titer (> 5g/L)

Optimized CLD

State-of-the-Art IP

The Core of CLD and Microbial Optimization

Is The Right Host Strain-Plasmid Combination

KBI Biopharma uses a streamlined process to shift from microfermentation to our largest working volumes. Our CLD expertise paired with our cutting-edge optimization improves throughput and shortens timelines. During this process, titers can be proportionally and accurately measured at very small volumes to identify a strain-plasmid combination that yields an optimized cell line.

Leveraging 10+ years of E. coli-based production and industry-leading microbial expertise
Optimized CLD for secreted antibody fragments (FABs), inclusion bodies (IBs), and soluble intracellular molecules
Heightened focus on screening scalable fermentation conditions
Innovative workflows leveraging high-throughput robotics and microfermentation technologies
State-of-the-art IP around our cell development and scalable processes
Built for small- and large-scale cGMP manufacturing
FDA/EMA Inspected Facilities
Well-versed in first-in-human (FIH) studies, late-stage manufacturing, and commercialization

We quickly develop robust, scalable protein manufacturing processes through in silico protein analysis, combined with wet lab IP and industry-leading screening workflows.

Download the Fact Sheet:

Biologics manufacturing using high-density microbial fermentation

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