Specific
Precision-engineered for a broad range of molecules
Unique
Proprietary platform built on patented technologies
Robust
Rapid, reliable, and versatile for producing recombinant proteins
Efficient
Streamlined and timely from early-stage to GMP manufacturing
Intentional Workflow for Rapid, Scaled Impact
Top-quality materials and methods for best-in-class development programs:
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ClonePix enables a first screening of high producer pools from an early stage. By combining cell colony imaging technologies with labeling of your molecule, only the highest-expressing and viable pools pass the screening step. The robustness of the ClonePix step provides your project with a high degree of security and confidence, right from the start.
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Our experts will select and load the most promising pools into Beacon® chips for export and clone isolation. This cutting-edge technology provides visual proof of monoclonality, ensuring the cell line is clonal in origin before moving to RCB banking. This method of monoclonality proof is commonly accepted as the highest proof by regulatory agencies, offering an even more robust confirmation of monoclonality than the traditional statistical calculation from FACS or limited dilution methodologies.
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We make SURE your mAb will be expressed in the best cell line — one that is made to last and will drive you to the highest-possible production levels with minimal risk. Our RCB lead identification and stability assessment steps are both performed in 14-day fed-batch processes, in the Ambr 15® system. This system is a mini-bioreactor that is fully representative of the performance you can expect in scale-up to large volume manufacturing conditions. Additionally, the Ambr 15® system enables continuous and non-invasive monitoring and optimization of all conditions — including shape, materials, shear stress, stirring conditions, and fine-tuned monitoring of vitamins, nutrients, O2, pH, and other critical conditions that impact performance.
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Within our SUREmAb offering, we have proven the stability of our proprietary SURE CHO-M Cell Line over 60 generations, ensuring the ongoing robustness and success of your CLD for your mAb project.
