Comprehensive Size Distribution Analysis of Adeno-Associated Virus Fill States
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In support of developing “gold standard” analytical workflows that streamlines and optimizes characterization of the various capsid fill states that are present in AAV products, the team at KBI Biopharma performed a comprehensive and targeted comparison of SV-AUC combined with MWA with two orthogonal separation methods: sedimentation equilibrium (SE) CsCl density gradient analysis and size exclusion chromatography coupled with multiple angle light scattering (SEC-MALS).
