Microbial Cell Line Development
KBI applies proven, well-characterized, off-the-shelf, or engineered microbial recombinant protein expression systems to provide state-of-the-art cell line development. KBI leverages high throughput fermentation and analytical screening tools to rapidly identify the most promising expression strategy, including tailored approaches based on protein chemistry and structural assessment. Typical expression systems will drive soluble or insoluble protein accumulation in the cytosol, and periplasmic accumulation can be employed in specialized cases depending on the protein of interest. In instances where expression favors insoluble protein accumulation in inclusion bodies (IBs), KBI develops high-yielding recovery processes with the analytical characterization of conversion to an active product by solubilization and refolding procedures.
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